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Dr. Neelaka Molagoda

BSc, MSc, PhD

Lecturer (Probationary)
neelakagm2012@gmail.com

 

Biography

Dr Neelaka Molagoda joined the department of Bioprocess Technology Faculty of Technology, in November 2021. He obtained a scholarship for postgraduate studies at Jeju National University from March 2016, onwards where he got the hands on experience of culturing a wide range of animal cells including primary cells and cell lines, in-vivo zebrafish handling and microinjections and several cutting edge biotechnology-related techniques such as bacterial transformation, small interference RNA (siRNA) mediated gene silencing, PCR, western blot analysis, flow cytometry, enzyme activity assays and confocal microscopy etc. Furthermore, he has explored the mechanisms of drug actions in several nutraceuticals focusing on anti- inflammatory, anti oxidative, anti-cancer, anti-melanogenic, anti-angiogenic activities as well as the effect on osteoblast differentiation and growth promotion etc. His PhD project was based on “Discovering various pharmaceutical aspects of dietary flavonoid fisetin including anti- inflammatory, anti-oxidative, and melanogenic effects as well as the effect on osteoblast differentiation” and awarded with the Dean’s award for the Excellent PhD research. Prior to converting to doctorate, I was awarded an M.Sc. in Life Sciences at Jeju University with first class honors.

He also possessed a four-year BSc. degree in Agriculture Technology and Management, specializing in Agricultural Biology from the University of Peradeniya, Sri Lanka. He holds an Honors Degree with a Second Class Upper. Additionally, he was awarded with S. F. H. Perera memorial prize for the Best Final Year Academic Performances based on his excellent academic merit.

 

Teaching programs and modules

BPT 4206: Pharmaceutical Biotechnology
BPT 4301: Drug Designing
BPT 3207: Enzyme Technology
BPT 3209: Scientific Writing
BPT 4207: Bioproduct Development
CML 1201: Personality Development

Awards and external recognitions

Awards:

  1. Dean’s award for the Excellent PhD. Research, Department of Marine Life Sciences, Jeju National University, 2021
  2. S.F.H. Perera Memorial Prize for the Best Final Year Academic Performances. Faculty of Agriculture, University of Peradeniya, 2015
  3. Best Oral Presentation – 59th Annual Meeting and International Symposium of Korean Society of Life Sciences, 2018
  4. Best Researcher Award – 59th Annual Meeting and International Symposium of Korean Society of Life Sciences, 2018
  5. Best Poster Award – 62nd Annual Meeting and International Symposium of Korean Society of Life Sciences, 2020
  6. Successfully completed the Animal Experimental Ethics certificate course (Ref no: 2019- O-0081). Animal Experimentation Ethics Committee, Jeju National University

Memberships:

  1. Vice President of Biology Guild, Department of Agricultural Biology, Faculty of
    Agriculture, University of Peradeniya, 2014
  2. Member of Korean Research Institute (KRI), from 2017 (Science NO: 11646406)
  3. Third step Brain Korea 21 (2016-2020)- The Ministry of Education, Republic of Korea Development of functional food products with natural materials derived marine resources No: 20170285 (2017-2022)- The Ministry of Oceans and Fisheries, Republic of Korea
  4. Basic Science Research Program through the National Research Foundation of Korea (NRF)2018R1D1A1B07045460 (2018-2021)- The Ministry of Education, Republic of Korea
Selected publications

Indexed Articles

  1. Molagoda, I. M. N., Kavinda, M. H. D., Choi, Y. H., Lee, H., Kang, C.-H., Lee, M.-H., Kim, G.-Y. (2021). Fisetin Protects HaCaT Human Keratinocytes from Fine Particulate Matter (PM2.5)-Induced Oxidative Stress and Apoptosis by Inhibiting the Endoplasmic Reticulum Stress Response. Antioxidants, 10(9), 1492.
  2. Molagoda, I. M. N., Kavinda, M. H. D., Ryu, H. W., Choi, Y. H., Jeong, J.-W., Kang, S., Kim, G.-Y. (2021). Gamma-Aminobutyric Acid (GABA) Inhibits α-Melanocyte-Stimulating Hormone-Induced Melanogenesis through GABAA and GABAB Receptors. International Journal of Molecular Sciences, 22(15), 8257.
  3. Molagoda, I.M.N., Athapaththu, A.M.G.K., Choi, Y.H., Park, C., Jin, C.-Y., Kang, C.-H., Lee, M.-H., Kim, G.-Y., 2021b. Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants 10, 1215.
  4. Molagoda, I.M., Lee, K.-T., Athapaththu, A.M., Choi, Y.-H., Hwang, J., Sim, S.-J., Kang, S., Kim, G.-Y., 2021a. Flavonoid Glycosides from Ziziphus jujuba var. inermis (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. Int J Mol Sci 22.
  5. Molagoda, I.M.N., Kang, C.-H., Lee, M.-H., Choi, Y.H., Lee, C.-M., Lee, S., Kim, G.-Y., 2021c. Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis. Biochemical Pharmacology 192, 114676.
  6. Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Jayasooriya, R.G.P.T., Kang, C.-H., Kim, G.-Y., 2021. Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock. Scientific Reports 11, 8377.
  7. Molagoda, I.M.N., Lee, K.T., Choi, Y.H., Jayasingha, J.A.C.C., Kim, G.-Y., 2021. Anthocyanins from Hibiscus syriacus L. Inhibit NLRP3 Inflammasome in BV2 Microglia Cells by Alleviating NFκB- and ER Stress-Induced Ca2+ Accumulation and Mitochondrial ROS Production. Oxidative Medicine and Cellular Longevity 2021, 1246491
  8. Molagoda, I.M.N., Karunarathne, W.A.H.M., Choi, Y.H., Park, S.R., Lee, S., Kim, G.-Y., 2021. Bisphenol A: A potential Toll-like receptor 4/myeloid differentiation factor 2 complex agonist. Environmental Pollution.
  9. Molagoda, I.M.N., Dilshara, M.G., Jayasooriya, R.G.P.T., Choi, Y.H., Park, C., Kim, G.- Y.,2020. Indirubin-3′-monoxime Induces Paraptosis in MDA-MB-231 Breast Cancer Cells by Transmitting Ca2+ from Endoplasmic Reticulum to Mitochondria. Archives of Biochemistry and Biophysics.
  10. Molagoda, I. M., Karunarathne, W. A., Lee, K. T., Choi, Y. H., Yu, S.-M., Kang, C.-H., & Kim, G.-Y. 2021. Protective Effect of Anthocyanin-Enriched Polyphenols from Hibiscus syriacus L. (Malvaceae) against Ultraviolet B-Induced Damage. Antioxidants, 10(4).
  11. Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Park, E.K., Jeon, Y.-J., Lee, B.-J., Kim, G.-Y., 2020. Fermented Oyster Extract Promotes Insulin-Like Growth Factor-1-Mediated
    Osteogenesis and Growth Rate. Mar. Drugs, 18, 472.
  12. Molagoda, I.M.N., Lee, K.T., Choi, Y.H., Kim, G.-Y., 2020. Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress-mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway. Antioxidants 9, 42.
  13. Molagoda, I.M.N., Choi, Y.H., Lee, S., Sung, J., Lee, C.R., Lee, H.G., Lim, J., Lee, K.-J., Jeon, Y.-J., Ma, J., Kim, G.-Y., 2020. Ethanolic Extract of Hippocampus abdominalis Exerts Anti-melanogenic Effects in B16F10 Melanoma Cells and Zebrafish Larvae by Activating the ERK Signaling Pathway. Cosmetics 7, 1.
  14. Molagoda, I.M.N., Karunarathne, W.A.H.M., Park, S.R., Choi, Y.H., Park, E.K., Jin, C.-Y., Yu, H., Jo, W.S., Lee, K.T., Kim, G.-Y., 2020. GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae through β-Catenin Activation. International Journal of Molecular Sciences 21, 312.
  15. Molagoda, I.M.N., Karunarathne, W.A.H.M., Choi, Y.H., Park, E.K., Jeon, Y.-J., Lee, B.-J., Kang, C.-H., Kim, G.-Y., 2019. Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the Wnt/β-Catenin Signaling Pathway, Leading to Bone Formation. Biomolecules 9, 711.
  16. Molagoda, I.M.N., Lee, S., Jayasooriya, R.G.P.T., Jin, C.-Y., Choi, Y.H., Kim, G.-Y., 2019. Deoxynivalenol Enhances IL-1β Expression in BV2 Microglial Cells Through Activation of the NF-κB Pathway and the ASC/NLRP3 Inflammasome. EXCLI journal 18, 356.
  17. Molagoda, I.M.N., Choi, Y.H., Lee, S., Jin, C.-Y., Kim, G.-Y., 2019. Deoxynivalenol Increases the Expression of Pro-Inflammatory Genes and Mediators Accompanied by NF- κB Activation. Latin American Journal of Pharmacy 38, 388-395.
  18. Molagoda, I.M.N., Dilshara, M.G., Jayasooriya, R.G.P.T., Choi, Y.H., Park, C., Lee, K.T., Lee, S., Kim, G.-Y., 2019. p53-Mediated Oxidative Stress Enhances Indirubin-3′- Monoxime-induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-related Apoptosis-Inducing Ligand Expression. Antioxidants 8, 423.
  19. Molagoda, I.M.N., Jin, C.-Y., Karunarathne, W.A.H.M., Kang, S.-H., Park, C., Kim, G.-Y., Choi, Y.H., 2018a. TRAIL Attenuates Sulforaphane-mediated Nrf2 and Sustains ROS Generation, Leading to Apoptosis of TRAIL-resistant Human Bladder Cancer Cells. Toxicology and Applied Pharmacology 352, 132-141.
  20. Molagoda, I.M.N., Jin, C.-Y., Park, C., Kwon, T.K., Yun, S.-J., Kim, W.J., Kim, G.-Y., Choi, Y.H., 2018. Piceatannol-induced Apoptosis is Reversed by N-acetyl-l-cysteine Through Restoration of XIAP Expression. Biological and Pharmaceutical Bulletin 41, 1372- 1378.

Selected Abstracts

  1. Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Kim, G.-Y., 2020. Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the wnt/β-catenin Signaling Pathway, Leading to bone formation. Orally presented at the 62nd Annual Meeting and International Symposium of Korean Society of Life Sciences, 2020. Daegu, South Korea.
  2. Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Kim, G.-Y., 2020. Fisetin Negatively Targets GSK 3β and Subsequently Activates β-catenin, Causing Melanogenesis. (Awarded as the best poster). Poster presentation at the 62nd Annual Meeting and International Symposium of Korean Society of Life Sciences, 2020. Daegu, South Korea.
  3. Molagoda, I.M.N., Karunarathne, W.A.M.I., Lee, S., Choi, Y.H., Kim, G.-Y., 2019. GSK-3β Targeting Fisetin Promotes Melanogenesis Through β-catenin Activation. Poster presentation at 4th International Conference on Natural products Utilization: From plants to pharmacy shelf, 2019. Bulgaria.
  4. Molagoda, I.M.N., Karunarathne, W.A.M.I., Lee, K.T., Choi, Y.H., Jayasooriya, R.G.P.T., and Kim, G.-Y., 2019. Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress- Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway. Poster presentation at 2019 Korea Plant Resources Association general meeting and fall conference Daegu, South Korea.
  5. Molagoda, I.M.N., Karunarathne, W.A.H.M., Park, E.K., Choi, Y.H. and Kim, G.-Y., 2018. Fisetin Promotes IL-18 Production by Activating Proteinase During Melanogenesis, Leading to Stimulation of Macrophages. Poster presentation at 2018 fall international convection of the pharmaceutical society of Korea, 2018. Jeju Island, South Korea.
  6. Molagoda, I.M.N., Karunarathne, W.A.H.M., Park, E.K., Choi, Y.H., Lee, B.J., Jeon, Y.J., Kim, G.-Y., 2018. γ-Aminobuteric Acid- enriched Fermented Oyster Stimulates Osteoblast Differentiation and Activation Leading Promotion of Bone Formation. Poster presentation at the 59th Annual Meeting and International Symposium of Korean Society of Life Sciences, 2018. Gwangju, South Korea.
  7. Molagoda, I.M.N., Lee, K.T., Kang, C.H., Choi, Y.H., Kim, G.-Y., 2018. Derrone Attenuate Belomycine-induced Lung Inflammation and Fibrosis. Poster presentation at the 59th Annual Meeting and International Symposium of Korean Society of Life Sciences,
    2018. Gwangju, South Korea.
  8. Molagoda, I.M.N., Karunarathne, W.A.H.M., Choi, Y.H., Kim, G.-Y., 2018. Fisetin Promotes IL-18 Production by Activating Proteinase-3 During Melanogenesis Leading to Stimulation of Macrophages. Orally presented at the 59th Annual Meeting and International Symposium of Korean Society of Life Sciences, 2018. Gwangju, South Korea. (Awarded as the best oral presentation)
  9. Molagoda, I.M.N., Lee, S., Choi, Y.H., Kim, G.-Y., 2017. Deoxynivalenol Triggers
    ATP/LPS Induced Inflammasome in BV2 Microglia Cells by Activating Inflammasome – mediated IL-1β. Poster presentation at 31st EFFoST international conference, Sitiges, Spain.
Working Experience and Employment History
  1. Worked as postdoctoral fellow at the Research Institute of Basic Sciences at Jeju National University (From 2022 March to 2022 November).
  2. Working as Lecturer (probationary) at the Department of Bioprocess Technology, Faculty of Technology, Rajarata University of Sri Lanka (From 2022 November to present).